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I received this interesting response from a reader of my pages. He had sent me the results of a search on psoriasis; my comments are at the end of this page with the marginal marks >>; Gary's response is margined >
>I used the following top down epidemiological
>reasoning to form a hypothesis that I then tried to
>validate from Medline at every possible point.
>1. psoriasis almost always appears after late teens
>and worsens with age.(typical unchecked insulin
>resistance syndrome progression).
>2. psoriasis clears under conditions of starvation or
>malnutrition(ketosis or borderline ketosis which
>implies glucose/insulin control) as cited in prisoner
>of war camps.
>3. psoriasis clears in some pregnant women and gets
>worse in others. I beieve this could be that some
>women go into ketosis(improve) and some become
>4. psoriasis has an overrepresentation of syndrome X
>coexisiting complications ie. hypertension,
>hyperlipidism, artherosclerosis and diabetes.
>To cut a long story short insulin resistance/glucose
>intolerance can explain all the above points. Some
>have a weak correlation and some points have a strong
>correlation. Taken together I believe the case is
>Given my 4 points above I believe it is unlikely that
>psoriasis is the cause of all the associated
>conditions, but rather insulin resistance is the
>cause and psoriasis is one of the effects.
>Much investigation still needs to be done with direct
>Thanks for the new pages. I have used your pages as a
>reference for myself and explanation source in my
>correspondence with others.
>>---"Allen E. Gale" <email@example.com> wrote:
>> Hi Gary
>> I have had time this evening to do justice to the
>>incredible information you retrieved on the
>>relationship between IR & psoriasis.
>> Where did you retrieve this from? Medline? and what
>>were the search words?
>> How it could work is that increased IR is a
>CONSEQUENCE of psoriasis.
>> (Just as increased IR is a consequence of any
>>stress, infection, pregnancy in women, trauma,
>>----the list grows)
>> The other diseases of IR then flow on as a
>>consequence of the increased IR due to the psoriasis.
>> Do you follow my line of thinking; The operative
>>word is "consequence".
>> May15 1999
It is relevant that Bernstein reports a high incidence of psoriasis in diabetics attending his clinic.
Personal communication 2001
Allen E Gale
May 5 2002