Kelley DE et al 2002

Skeletal muscle contains the majority of the body's glycogen stores and a similar amount of readily accessible energy as intramyocellular triglyceride (imTG). In health muscles use either lipid or carbohydrate as fuel, and switches between these fuels. But in type 2 diabetes and obesity, skeletal muscle has difficulty in switching between lipid and carbohydrate fuels. This inflexibility in fuel selection appears to be related to the accumulation of imTG. This is an important aspect of insulin resistance of skeletal muscle.

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